Best in the Bigs is an inset set in 2000 Upper Deck Pros and Prospects. This 10-card set was inserted at a rate of 1:12 packs.
Gallery[]
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Checklist[]
| Number | Player | Team |
| 1 | Sammy Sosa | Cubs |
| 2 | Tony Gwynn | Padres |
| 3 | Pedro Martinez | Red Sox |
| 4 | Mark McGwire | Cardinals |
| 5 | Chipper Jones | Braves |
| 6 | Derek Jeter | Yankees |
| 7 | Ken Griffey Jr. | Reds |
| 8 | Cal Ripken | Orioles |
| 9 | Greg Maddux | Braves |
| 10 | Ivan Rodriguez | Rangers |
Template:2000 Upper Deck Pros and Prospects