Significant Signatures is an insert set in 2005 Donruss Classics.
Gallery[]
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Checklist[]
| Number | Player | Team | Silver PR | Gold PR | Platinm PR |
| 1 | Scott Rolen | Cardinals | 1 | 1 | 1 |
| 3 | Jose Vidro | Expos | 10 | 5 | 1 |
| 6 | Jose Guillen | Pirates | 10 | 5 | 1 |
| 7 | Trot Nixon | Red Sox | 10 | 5 | 1 |
| 8 | Mark Loretta | Padres | 10 | 5 | 1 |
| 9 | Jody Gerut | Indians | 10 | 5 | 1 |
| 11 | Barry Larkin | Reds | 1 | 1 | 1 |
| 13 | Carl Crawford | Devil Rays | N/A | N/A | 1 |
| 14 | Paul Konerko | White Sox | 10 | 5 | 1 |
| 15 | Jim Edmonds | Cardinals | 1 | 1 | 1 |
| 16 | Garret Anderson | Angels | N/A | 5 | 1 |
| 17 | Jay Gibbons | Orioles | 25 | 10 | 1 |
| 19 | Mike Lowell | Marlins | 1 | 1 | 1 |
| 21 | Josh Beckett | Marlins | 1 | 1 | 1 |
| 22 | Tim Salmon | Angels | 100 | 50 | 1 |
| 23 | Shannon Stewart | Twins | 10 | 5 | 1 |
| 24 | Miguel Cabrera | Marlins | 10 | 5 | 1 |
| 26 | Kevin Youkilis | Red Sox | 25 | 10 | 1 |
| 28 | Austin Kearns | Reds | 10 | 5 | 1 |
| 29 | Cliff Lee | Indians | 200 | 100 | 1 |
| 32 | Roy Halladay | Blue Jays | 1 | 1 | 1 |
| 34 | David Ortiz | Red Sox | 10 | 5 | 1 |
| 35 | Dontrelle Willis | Marlins | 1 | 1 | 1 |
| 36 | Craig Wilson | Pirates | 1 | 1 | 1 |
| 37 | Jeff Suppan | Cardinals | 200 | 100 | 1 |
| 38 | Curt Schilling | Red Sox | 1 | 1 | 1 |
| 39 | Larry Bigbie | Orioles | 100 | 50 | 1 |
| 40 | Rich Harden | A's | 100 | 50 | 1 |
| 41 | Victor Martinez | Indians | 25 | 10 | 1 |
| 43 | Joey Gathright | Royals | 100 | 50 | 1 |
| 44 | Adam Dunn | Reds | 5 | 5 | 1 |
| 45 | Pedro Martinez | Mets | 1 | 1 | 1 |
| 47 | Tom Glavine | Mets | 1 | 1 | 1 |
| 48 | Torii Hunter | Twins | 5 | 5 | 1 |
| 49 | Angel Berroa | Royals | 10 | 10 | 1 |
| 50 | Mark Prior | Cubs | 1 | 1 | 1 |
| 52 | CC Sabathia | Indians | 10 | 5 | 1 |
| 54 | Shigetoshi Hasegawa | Mariners | 10 | 5 | 1 |
| 55 | Brandon Webb | Diamondbacks | 10 | 5 | 1 |
| 56 | Mark Buehrle | White Sox | 10 | 5 | 1 |
| 57 | Johan Santana | Twins | 10 | 5 | 1 |
| 58 | Francisco Rodriguez | Angels | 10 | 10 | 1 |
| 61 | Jake Peavy | Padres | 25 | 10 | 1 |
| 62 | Akinori Otsuka | Padres | 10 | 5 | 1 |
| 63 | Dioner Navarro | Dodgers | 100 | 50 | 1 |
| 64 | Kazuhito Tadano | Indians | 100 | 50 | 1 |
| 65 | Ryan Wagner | Reds | 50 | 25 | 1 |
| 66 | Abe Alvarez | Red Sox | 100 | 50 | 1 |
| 68 | Jermaine Dye | White Sox | 25 | 10 | 1 |
| 69 | Todd Walker | Cubs | 25 | 10 | 1 |
| 70 | Octavio Dotel | A's | 25 | 10 | 1 |
| 71 | Frank Thomas | White Sox | 1 | 1 | 1 |
| 73 | Scott Podsednik | Brewers | 25 | 10 | 1 |
| 74 | BJ Upton | Devil Rays | 10 | 5 | 1 |
| 75 | Barry Zito | A's | 1 | 1 | 1 |
| 76 | Raul Ibanez | Mariners | 50 | 25 | 1 |
| 77 | Orlando Cabrera | Red Sox | 25 | 10 | 1 |
| 78 | Sean Burroughs | Padres | 10 | 5 | 1 |
| 79 | Esteban Loaiza | Yankees | 50 | 25 | 1 |
| 82 | Shingo Takatsu | White Sox | 10 | 5 | N/A |
| 84 | David Dellucci | Rangers | 50 | 25 | 1 |
| 85 | Travis Blackley | Mariners | 200 | 100 | 1 |
| 86 | Brad Penny | Dodgers | 25 | 5 | 1 |
| 87 | Nick Johnson | Expos | 10 | 5 | 1 |
| 88 | Brian Roberts | Orioles | 100 | 50 | 1 |
| 90 | Mike Lieberthal | Phillies | 25 | 10 | 1 |
| 91 | Craig Biggio | Astros | 1 | 1 | 1 |
| 92 | Sean Casey | Reds | 10 | 5 | 1 |
| 94 | Milton Bradley | Dodgers | 100 | 50 | 1 |
| 96 | Adrian Gonzalez | Padres | 200 | 100 | 1 |
| 97 | Chad Tracy | Diamondbacks | 100 | 50 | 1 |
| 98 | Chad Cordero | Expos | 100 | 50 | 1 |
| 99 | Albert Pujols | Cardinals | 1 | 1 | 1 |
| 100 | Jason Kubel | Twins | 200 | 50 | 1 |
| 101 | Rafael Furcal | Braves | 10 | 5 | 1 |
| 102 | Jack Wilson | Pirates | 100 | 50 | 1 |
| 103 | Eric Chavez | A's | 1 | 1 | 1 |
| 104 | Casey Kotchman | Angels | 100 | 50 | 1 |
| 105 | Jeff Bagwell | Astros | 1 | 1 | 1 |
| 106 | Melvin Mora | Orioles | 100 | 50 | 1 |
| 107 | Bobby Crosby | A's | 100 | 50 | 1 |
| 110 | Vernon Wells | Blue Jays | 1 | 1 | 1 |
| 111 | Francisco Cordero | Rangers | 50 | 25 | 1 |
| 112 | Steve Finley | Angels | 10 | 5 | 1 |
| 113 | Omar Vizquel | Indians | 10 | 5 | 1 |
| 114 | Eric Byrnes | A's | 50 | 25 | 1 |
| 115 | Tim Hudson | Braves | 1 | 1 | 1 |
| 116 | Aramis Ramirez | Cubs | 10 | 5 | 1 |
| 117 | Lance Berkman | Astros | 1 | 1 | 1 |
| 118 | Shea Hillenbrand | Diamondbacks | 25 | 10 | 1 |
| 119 | Aubrey Huff | Devil Rays | 25 | 10 | 1 |
| 120 | Lew Ford | Twins | 25 | 10 | 1 |
| 121 | Sammy Sosa | Cubs | 1 | 1 | 1 |
| 123 | Rickie Weeks | Brewers | 10 | 5 | 1 |
| 124 | Manny Ramirez | Red Sox | 1 | 1 | 1 |
| 126 | Adam LaRoche | Braves | 25 | 10 | 1 |
| 128 | Ken Harvey | Royals | 50 | 25 | 1 |
| 129 | Adrian Beltre | Dodgers | 10 | 5 | 1 |
| 130 | Magglio Ordonez | White Sox | 10 | 5 | 1 |
| 131 | Greg Maddux | Cubs | 1 | 1 | 1 |
| 132 | Russ Ortiz | Diamondbacks | 25 | 10 | 1 |
| 133 | Jason Varitek | Red Sox | 1 | ||
| 134 | Kerry Wood | Cubs | 1 | 1 | 1 |
| 135 | Mike Mussina | Yankees | 1 | 1 | 1 |
| 136 | Joe Nathan | Twins | 100 | 50 | 1 |
| 138 | Carlos Zambrano | Cubs | 25 | 5 | 1 |
| 139 | Ben Sheets | Brewers | 10 | 5 | 1 |
| 140 | Jae Weong Seo | Mets | 10 | 5 | 1 |
| 141 | Derrek Lee | Cubs | 10 | 5 | 1 |
| 143 | John Lackey | Angels | 200 | 100 | 1 |
| 145 | Dewon Brazelton | Devil Rays | 200 | 100 | 1 |
| 146 | Jason Bay | Pirates | 25 | 10 | 1 |
| 147 | Alfonso Soriano | Rangers | 1 | 1 | 1 |
| 148 | Travis Hafner | Indians | 100 | 50 | 1 |
| 152 | Wade Miller | Astros | 50 | 25 | 1 |
| 154 | Scott Kazmir | Devil Rays | 25 | 10 | 1 |
| 156 | Livan Hernandez | Expos | 25 | 10 | 1 |
| 157 | Jose Capellan | Brewers | 10 | 5 | 1 |
| 158 | David Wright | Mets | 25 | 10 | 1 |
| 159 | Chone Figgins | Angels | 50 | 25 | 1 |
| 162 | Hideo Nomo | Dodgers | 1 | 1 | 1 |
| 163 | Merkin Valdez | Giants | 200 | 100 | 1 |
| 164 | Shawn Green | Diamondbacks | 1 | 1 | 1 |
| 165 | Alexis Rios | Blue Jays | 50 | 25 | 1 |
| 166 | Johnny Estrada | Braves | 200 | 100 | 1 |
| 167 | Danny Graves | Reds | 50 | 25 | 1 |
| 168 | Carlos Lee | White Sox | 25 | 10 | 1 |
| 170 | Randy Johnson | Yankees | 1 | 1 | 1 |
| 171 | Randy Wolf | Phillies | 25 | 10 | 1 |
| 173 | Chipper Jones | Braves | 1 | 1 | 1 |
| 174 | Delmon Young | Devil Rays | 10 | 5 | 1 |
| 175 | Edwin Jackson | Dodgers | 25 | 10 | 1 |
| 177 | Matt Clement | Cubs | 10 | 5 | 1 |
| 178 | Jacque Jones | Twins | 25 | 10 | 1 |
| 179 | Gary Sheffield | Yankees | 1 | 1 | 1 |
| 180 | Laynce Nix | Rangers | 200 | 100 | 1 |
| 181 | Tom Gordon | Yankees | 25 | 10 | 1 |
| 182 | Jose Castillo | Pirates | 100 | 50 | 1 |
| 185 | Paul Lo Duca | Marlins | 10 | 5 | 1 |
| 186 | Roger Clemens | Astros | 1 | 1 | 1 |
| 187 | Todd Helton | Rockies | 1 | 1 | 1 |
| 188 | Keith Foulke | Red Sox | 25 | 10 | 1 |
| 189 | Jeremy Bonderman | Tigers | 50 | 25 | 1 |
| 190 | Troy Percival | Angels | 25 | 10 | 1 |
| 191 | Michael Young | Rangers | 10 | 5 | 1 |
| 193 | Rafael Palmeiro | Orioles | 1 | 1 | 1 |
| 194 | Brett Myers | Phillies | 50 | 25 | 1 |
| 197 | Lyle Overbay | Brewers | 25 | 10 | 1 |
| 200 | Edgar Renteria | Red Sox | 10 | 5 | 1 |
| 201 | Justin Verlander | Tigers | 25 | 10 | 1 |
| 202 | Miguel Negron | Blue Jays | 100 | 50 | 1 |
| 204 | Paul Reynoso | White Sox | 100 | 50 | 1 |
| 205 | Colter Bean | Yankees | 100 | 50 | 1 |
| 206 | Raul Tablado | Blue Jays | 100 | 50 | 1 |
| 207 | Mark McLemore | Astros | 100 | 50 | 1 |
| 208 | Russ Rohlicek | Cubs | 100 | 50 | 1 |
| 210 | Chris Seddon | Devil Rays | 100 | 50 | 1 |
| 213 | Mike Morse | Mariners | 100 | 50 | 1 |
| 217 | Carlos Ruiz | Phillies | 100 | 50 | 1 |
| 218 | Chris Roberson | Phillies | 100 | 50 | 1 |
| 219 | Ryan Speier | Rockies | 100 | 50 | 1 |
| 221 | Ambiorix Burgos | Royals | 100 | 50 | 1 |
| 223 | Dave Gassner | Twins | 100 | 50 | 1 |
| 224 | Sean Tracey | White Sox | 100 | 50 | 1 |
| 225 | Chris Rogowski | White Sox | 100 | 50 | 1 |
| 226 | Billy Williams LGD | Cubs | 10 | 5 | 1 |
| 227 | Ralph Kiner LGD | Pirates | 10 | 5 | 1 |
| 228 | Ozzie Smith LGD | Padres | 10 | 5 | 1 |
| 229 | Rod Carew LGD | Twins | 5 | 1 | 1 |
| 230 | Nolan Ryan LGD | Mets | 5 | 1 | 1 |
| 231 | Fergie Jenkins LGD | Rangers | 10 | 5 | 1 |
| 232 | Paul Molitor LGD | Twins | 10 | 5 | 1 |
| 233 | Carlton Fisk LGD | White Sox | 5 | 1 | 1 |
| 234 | Rollie Fingers LGD | A's | 10 | 5 | 1 |
| 235 | Lou Brock LGD | Cardinals | 10 | 5 | 1 |
| 236 | Gaylord Perry LGD | Padres | 25 | 10 | 1 |
| 237 | Don Mattingly LGD | Yankees | 5 | 1 | 1 |
| 238 | Maury Wills LGD | Dodgers | 10 | 5 | 1 |
| 239 | Luis Aparicio LGD | Orioles | 10 | 5 | 1 |
| 240 | George Brett LGD | Royals | 5 | 1 | 1 |
| 241 | Mike Schmidt LGD | Phillies | 5 | 1 | 1 |
| 243 | Dennis Eckersley LGD | A's | 10 | 5 | 1 |
| 244 | Reggie Jackson LGD | Yankees | 5 | 1 | 1 |
| 245 | Bobby Doerr LGD | Red Sox | 25 | 10 | 1 |
| 246 | Bob Feller LGD | Indians | 25 | 10 | 1 |
| 247 | Cal Ripken LGD | Orioles | 5 | 1 | 1 |
| 248 | Harmon Killebrew LGD | Twins | 10 | 5 | 1 |
| 249 | Frank Robinson LGD | Orioles | 10 | 5 | 1 |
| 250 | Stan Musial LGD | Cardinals | 5 | 1 | 1 |
| Base Set |
| Insert Sets |
| Significant Signatures - Classic Combos - Classic Singles - Dress Code - Homerun Heroes - Legendary Lumberjacks |
| Legendary Players - Membership - Stars of Summer - Team Colors - Team Colors Game Used - Team Colors Autographs |
| Other Information |
| Card Images - Box Breaks |
| Other Donruss Classics Sets |
| 2001 - 2002 - 2003 - 2004 |
| Panini Classic Sets |
| 2014 |