The 'Base Set of 2009 Topps. Cards 1-330 were released in Series 1.
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Checklist[]
| Number | Player | Team | Special |
| 1 | Alex Rodriguez | Yankees | |
| 1 | Babe Ruth | Yankees | SP |
| 2 | Omar Vizquel | Giants | |
| 2 | Pee Wee Reese | Dodgers | SP |
| 3 | Andy Marte | Indians | |
| 4 | Chipper / Pujols/ Holliday | Multi | LL |
| 5 | John Lackey | Angels | |
| 6 | Raul Ibanez | Mariners | |
| 7 | Mickey Mantle | Yankees | |
| 8 | Terry Francona MG | Red Sox | |
| 9 | Dallas McPherson | Marlins | |
| 10 | Dan Uggla | Marlins | |
| 10 | Rogers Hornsby | Cardinals | SP |
| 11 | Fernando Tatis | Mets | |
| 12 | Andrew Carpenter | Phillies | (RC) |
| 13 | Ryan Langerhans | Nationals | |
| 14 | Jon Rauch | Diamondbacks | |
| 15 | Nate McLouth | Pirates | |
| 16 | Evan Longoria | Rays | Highlight |
| 17 | Bobby Cox MG | Braves | |
| 18 | George Sherrill | Orioles | |
| 19 | Edgar Gonzalez | Padres | |
| 20 | [rad Lidge | Phillies | |
| 21 | Jack Wilson | Pirates | |
| 22 | Longoria / Price | Rays | CC |
| 23 | Gerald Laird | Rangers | |
| 24 | Frank Thomas | A's | |
| 25 | Jon Lester | Red Sox | |
| 26 | Jason Giambi | Yankees | |
| 27 | Jonathon Niese | Mets | RC |
| 28 | Mike Lowell | Red Sox | |
| 29 | Jerry Hairston | Reds | |
| 30 | Ken Griffey Jr. | White Sox | |
| 30 | Jackie Robinson | Dodgers | SP |
| 31 | Ian Stewart | Rockies | |
| 32 | Daric Barton | A's | |
| 33 | Jose Guillen | Royals | |
| 34 | Brandon Inge | Tigers | |
| 35 | David Price | Rays | (RC) |
| 36 | Kevin Slowey | Twins | |
| 37 | Erick Aybar | Angels | |
| 38 | Eric Wedge MG | Indians | |
| 39 | Stephen Drew | Diamondbacks | |
| 40 | Carl Crawford | Rays | |
| 41 | Mike Mussina | Yankees | |
| 42 | Jeff Francoeur | Braves | |
| 43 | Mauer / Pedroia / Bradley | Multi | LL |
| 44 | Geoff Jenkins | Phillies | |
| 44 | Barack Obama | USA | SP |
| 45 | Aubrey Huff | Orioles | |
| 46 | Brad Ziegler | A's | |
| 47 | Jose Valverde | Astros | |
| 48 | Mike Napoli | Angels | |
| 49 | Kazuo Matsui | Astros | |
| 50 | David Ortiz | Red Sox | |
| 51 | Will Venable | Padres | (RC) |
| 52 | Marco Scutaro | Blue Jays | |
| 53 | Jonathan Sanchez | Giants | |
| 54 | Dusty Baker MG | Reds | |
| 55 | J.J. Hardy | Brewers | |
| 56 | Edwin Encarnacion | Reds | |
| 57 | Jo-Jo Reyes | Braves | |
| 58 | Travis Snider | Blue Jays | (RC) |
| 59 | Eric Gagne | Brewers | |
| 60 | Mariano Rivera | Yankees | |
| 60 | Cy Young | Naps | SP |
| 61 | Berkman / Lee | Astros | CC |
| 62 | Brian Barton | Cardinals | |
| 63 | Josh Outman | A's | (RC) |
| 64 | Miguel Montero | Diamondbacks | |
| 65 | Mike Pelfrey | Mets | |
| 66 | Dustin Pedroia | Red Sox | |
| 66 | Ty Cobb | Tigers | SP |
| 67 | Andruw Jones | Dodgers | |
| 68 | Kyle Lohse | Cardinals | |
| 69 | Rich Aurilia | Giants | |
| 70 | Jermaine Dye | White Sox | |
| 71 | Mat Gamel | Brewers | (RC) |
| 72 | David Dellucci | Indians | |
| 73 | Shane Victorino | Phillies | |
| 74 | Trey Hillman MG | Royals | |
| 75 | Rich Harden | Cubs | |
| 76 | Marcus Thames | Tigers | |
| 77 | Jed Lowrie | Red Sox | |
| 78 | Tim Lincecum | Giants | |
| 79 | David Eckstein | Diamondbacks | |
| 80 | Brian McCann | Braves | |
| 81 | Howard / Dunn / Delgado | Multi | LL |
| 82 | Miguel Cairo | Mariners | |
| 83 | Ryan Garko | Indians | |
| 84 | Rod Barajas | Blue Jays | |
| 85 | Justin Verlander | Tigers | |
| 86 | Kila Kaaihue | Royals | (RC) |
| 87 | Brad Hawpe | Rockies | |
| 88 | Fredi Gonzalez MG | Marlins | |
| 89 | Jon Lester/Jason Bay | Red Sox | Highlight |
| 90 | Justin Morneau | Twins | |
| 91 | Cody Ross | Marlins | |
| 92 | Luis Castillo | Mets | |
| 93 | James Parr | Braves | (RC) |
| 94 | Adam Lind | Blue Jays | |
| 95 | Andrew Miller | Marlins | |
| 96 | Dexter Fowler | Rockies | (RC) |
| 97 | Willie Harris | Nationals | |
| 98 | Akinori Iwamura | Rays | |
| 99 | Juan Castro | Orioles | |
| 100 | David Wright | Mets | |
| 101 | Nick Hundley | Padres | |
| 102 | Garrett Atkins | Rockies | |
| 103 | Kyle Kendrick | Phillies | |
| 104 | Brandon Moss | Pirates | |
| 105 | Francisco Liriano | Twins | |
| 106 | Marlon Byrd | Rangers | |
| 107 | Pedro Feliz | Phillies | |
| 108 | Alcides Escobar | Brewers | (RC) |
| 109 | Tom Gorzelanny | Pirates | |
| 110 | Hideki Matsui | Yankees | |
| 111 | Troy Percival | Rays | |
| 112 | Hideki Okajima | Red Sox | |
| 113 | Chris Young | Padres | |
| 114 | Chris Dickerson | Reds | |
| 115 | Kevin Youkilis | Red Sox | |
| 115 | George Sisler | Browns | SP |
| 116 | Omar Infante | Braves | |
| 117 | Ron Gardenhire MG | Twins | |
| 118 | Josh Johnson | Marlins | |
| 119 | Craig Counsell | Brewers | |
| 120 | Mark Teixeira | Angels | |
| 121 | Greg Golson | Rangers | (RC) |
| 122 | Joe Mather | Cardinals | |
| 123 | Casey Blake | Dodgers | |
| 124 | Reed Johnson | Cubs | |
| 125 | Roy Oswalt | Astros | |
| 126 | Orlando Hudson | Diamondbacks | |
| 127 | Cabrera / Quentin / A-Rod | Multi | LL |
| 128 | Johnny Cueto | Reds | |
| 129 | Angel Berroa | Dodgers | |
| 130 | Vladimir Guerrero | Angels | |
| 131 | Joe Torre MG | Dodgers | |
| 132 | Juan Pierre | Dodgers | |
| 133 | Brandon Jones | Braves | |
| 134 | Evan Longoria | Rays | |
| 135 | Carlos Delgado | Mets | |
| 136 | Tim Hudson | Braves | |
| 137 | Angel Salome | Brewers | (RC) |
| 138 | Ubaldo Jimenez | Rockies | |
| 139 | Matt Stairs | Phillies | Highlight |
| 140 | Brandon Webb | Diamondbacks | |
| 141 | Mark Teahen | Royals | |
| 142 | Brad Penny | Dodgers | |
| 143 | Matt Joyce | Tigers | |
| 144 | Matt Tuiasosopo | Mariners | (RC) |
| 145 | Alex Gordon | Royals | |
| 146 | Glen Perkins | Twins | |
| 147 | Howard / Wright / A Gonz | Multi | LL |
| 148 | Ty Wigginton | Astros | |
| 149 | Juan Uribe | White Sox | |
| 150 | Kosuke Fukudome | Cubs | |
| 151 | Carl Pavano | Yankees | |
| 152 | Cody Ransom | Yankees | |
| 153 | Lastings Milledge | Nationals | |
| 154 | A.J. Pierzynski | White Sox | |
| 155 | Roy Halladay | Blue Jays | |
| 156 | Carlos Pena | Rays | |
| 157 | Webb / Haren | Diamondbacks | |
| 158 | Ray Durham | Brewers | |
| 159 | Matt Antonelli | Padres | (RC) |
| 160 | Evan Longoria | Rays | |
| 161 | Brendan Harris | Twins | |
| 162 | Mike Cameron | Brewers | |
| 163 | Ross Gload | Royals | |
| 164 | Bob Geren MG | A's | |
| 165 | Matt Kemp | Dodgers | |
| 166 | Jeff Baker | Rockies | |
| 167 | Aaron Harang | Reds | |
| 168 | Mark DeRosa | Cubs | |
| 169 | Juan Miranda | Yankees | RC |
| 170 | CC Sabathia | Brewers | |
| 170 | CC Sabathia | Yankees | SP |
| 171 | Jeff Bailey | Red Sox | |
| 172 | Yadier Molina | Cardinals | |
| 173 | Manny Delcarmen | Red Sox | |
| 174 | James Shields | Rays | |
| 175 | Jeff Samardzija | Cubs | |
| 176 | Hamilton / Morneau / Cabrera | Multi | LL |
| 177 | Eric Hinske | Rays | |
| 178 | Frank Catalanotto | Rangers | |
| 179 | Rafael Furcal | Dodgers | |
| 180 | Cliff Lee | Indians | |
| 181 | Jerry Manuel MG | Mets | |
| 182 | Daniel Murphy | Mets | (RC) |
| 183 | Jason Michaels | Pirates | |
| 184 | Bobby Parnell | Mets | (RC) |
| 185 | Randy Johnson | Diamondbacks | |
| 186 | Ryan Madson | Phillies | |
| 187 | Jon Garland | Angels | |
| 188 | Josh Bard | Padres | |
| 189 | Jay Payton | Orioles | |
| 190 | Chien-Ming Wang | Yankees | |
| 191 | Shane Victorino | Phillies | Highlight |
| 192 | Collin Balester | Nationals | |
| 193 | Zack Greinke | Royals | |
| 194 | Jeremy Guthrie | Orioles | |
| 195 | Tim Lincecum | Giants | |
| 195 | Christy Mathewson | Giants | SP |
| 196 | Jason Motte | Cardinals | (RC) |
| 197 | Ronnie Belliard | Nationals | |
| 198 | Conor Jackson | Diamondbacks | |
| 199 | Ramon Castro | Mets | |
| 200 | Chase Utley | Phillies | |
| 200 | Jimmie Foxx | A's | SP |
| 201 | Saltalamacchia / Hamilton | Rangers | CC |
| 202 | Gaby Sanchez | Marlins | (RC) |
| 203 | Jair Jurrjens | Braves | |
| 204 | Andy Sonnanstine | Rays | |
| 205 | Miguel Tejada | Astros | |
| 205 | Honus Wagner | Pirates | SP |
| 206 | Santana / Lincecum / Peavy | Multi | LL |
| 207 | Joe Blanton | Phillies | |
| 208 | James McDonald | Dodgers | (RC) |
| 209 | Alfredo Amezaga | Marlins | |
| 210 | Geovany Soto | Cubs | |
| 210 | Roy Campanella | Dodgers | SP |
| 211 | Ryan Rowland-Smith | Mariners | |
| 212 | Denard Span | Twins | |
| 213 | Jeremy Sowers | Indians | |
| 214 | Scott Elbert | Dodgers | (RC) |
| 215 | Ian Kinsler | Rangers | |
| 216 | Joe Maddon MG | Rays | |
| 217 | Albert Pujols | Cardinals | |
| 218 | Emmanuel Burriss | Giants | |
| 219 | Shin-Soo Choo | Indians | |
| 220 | Jay Bruce | Reds | |
| 221 | Cliff Lee / Halladay / D Matsuzaka | Multi | LL |
| 222 | Mark Sweeney | Dodgers | |
| 223 | Dave Roberts | Giants | |
| 224 | Max Scherzer | Diamondbacks | |
| 225 | Aaron Cook | Rockies | |
| 226 | Neal Cotts | Cubs | |
| 227 | Freddy Sandoval | Angels | (RC) |
| 228 | Scott Rolen | Blue Jays | |
| 229 | Cesar Izturis | Cardinals | |
| 230 | Justin Upton | Diamondbacks | |
| 231 | Xavier Nady | Yankees | |
| 232 | Gabe Kapler | Brewers | |
| 233 | Erik Bedard | Mariners | |
| 234 | John Russell MG | Pirates | |
| 235 | Chad Billingsley | Dodgers | |
| 236 | Kelly Johnson | Braves | |
| 237 | Aaron Cunningham | A's | (RC) |
| 238 | Jorge Cantu | Marlins | |
| 239 | Brandon League | Blue Jays | |
| 240 | Ryan Braun | Brewers | |
| 240 | Mel Ott | Giants | SP |
| 241 | David Newhan | Astros | |
| 242 | Ricky Nolasco | Marlins | |
| 243 | Chase Headley | Padres | |
| 244 | Sean Rodriguez | Angels | |
| 245 | Pat Burrell | Phillies | |
| 246 | Upton / Crawford / Longoria | Devil Rays | Highlight |
| 247 | Yuniesky Betancourt | Mariners | |
| 248 | Scott Lewis | Indians | (RC) |
| 249 | Jack Hannahan | A's | |
| 250 | Josh Hamilton | Rangers | |
| 251 | Greg Smith | A's | |
| 252 | Brandon Wood | Angels | |
| 253 | Edgar Renteria | Tigers | |
| 254 | Cito Gaston MG | Blue Jays | |
| 255 | Joe Crede | White Sox | |
| 256 | Reggie Abercrombie | Astros | |
| 257 | George Kottaras | Red Sox | (RC) |
| 258 | Casey Kotchman | Braves | |
| 259 | Lincecum / Haren / Santana | Multi | LL |
| 260 | Manny Ramirez | Dodgers | |
| 261 | Jose Bautista | Blue Jays | |
| 262 | Mike Gonzalez | Braves | |
| 263 | Elijah Dukes | Nationals | |
| 264 | Dave Bush | Brewers | |
| 265 | Carlos Zambrano | Cubs | |
| 266 | Todd Wellemeyer | Cardinals | |
| 267 | Michael Bowden | Red Sox | (RC) |
| 268 | Chris Burke | Diamondbacks | |
| 269 | Hunter Pence | Astros | |
| 270 | Grady Sizemore | Indians | |
| 270 | Tris Speaker | SP | |
| 271 | Cliff Lee | Indians | |
| 272 | Chan Ho Park | Dodgers | |
| 273 | Brian Roberts | Orioles | |
| 274 | Alex Hinshaw | Giants | |
| 275 | Alex Rios | Blue Jays | |
| 276 | Geovany Soto | Cubs | |
| 277 | Asdrubal Cabrera | Indians | |
| 278 | Philadelphia Phillies | Phillies | Highlight |
| 279 | Ryan Church | Mets | |
| 280 | Joe Saunders | Angels | |
| 281 | Tug Hulett | Mariners | |
| 282 | Chris Lambert | Tigers | (RC) |
| 283 | John Baker | Marlins | |
| 284 | Luis Ayala | Mets | |
| 285 | Justin Duchscherer | A's | |
| 286 | Odalis Perez | Nationals | |
| 287 | Greg Maddux | Dodgers | |
| 287 | Walter Johnson | Senators | SP |
| 288 | Guillermo Quiroz | Orioles | |
| 289 | Josh Banks | Padres | |
| 290 | Albert Pujols | Cardinals | |
| 290 | Lou Gehrig | Yankees | SP |
| 291 | Chris Coste | Phillies | |
| 292 | Francisco Cervelli | Yankees | (RC) |
| 293 | Brian Bixler | Pirates | |
| 294 | Brandon Boggs | Rangers | |
| 295 | Derrek Lee | Cubs | |
| 296 | Reid Brignac | Rays | |
| 297 | Bud Black MG | Padres | |
| 298 | Jonathan Van Every | Red Sox | |
| 299 | Cole Hamels | Phillies | Highlight |
| 300 | Ichiro Suzuki | Mariners | |
| 301 | Clint Barmes | Rockies | |
| 302 | Brian Giles | Padres | |
| 303 | Zach Duke | Pirates | |
| 304 | Jason Kubel | Twins | |
| 305 | Ivan Rodriguez | Yankees | |
| 305 | Thurman Munson | Yankees | SP |
| 306 | Javier Vazquez | White Sox | |
| 307 | Burnett / E Santana / Halladay | Multi | LL |
| 308 | Chris Duncan | Cardinals | |
| 309 | Humberto Sanchez | Yankees | (RC) |
| 310 | Johan Santana | Mets | |
| 311 | Kelly Shoppach | Indians | |
| 312 | Ryan Sweeney | A's | |
| 313 | Jamey Carroll | Indians | |
| 314 | Matt Treanor | Marlins | |
| 315 | Hiroki Kuroda | Dodgers | |
| 316 | Brian Stokes | Mets | |
| 317 | Jarrod Saltalamacchia | Rangers | |
| 318 | Manny Acta MG | Nationals | |
| 319 | Brian Fuentes | Rockies | |
| 320 | Miguel Cabrera | Tigers | |
| 320 | Johnny Mize | Cardinals | SP |
| 321 | Kazmir / Price | Rays | CC |
| 322 | John Buck | Royals | |
| 323 | Vicente Padilla | Rangers | |
| 324 | Mark Reynolds | Diamondbacks | |
| 325 | Dustin McGowan | Blue Jays | |
| 326 | Manny Ramirez | Dodgers | Highlight |
| 327 | Phil Coke | Yankees | (RC) |
| 328 | Doug Mientkiewicz | Pirates | |
| 329 | Gil Meche | Royals | |
| 330 | Daisuke Matsuzaka | Red Sox |